Understanding how titin affects muscle stiffness and sensing during activation.
Official title: Titin-based stiffness regulation and mechanosensing in activated skeletal muscle.
Funded at University of Arizona · NIH-10899638 · Data updated 2026-11-12
This study is looking at how a special protein called titin helps our muscles feel and respond when they move, using mice to see how it works during muscle contractions, which could help us understand muscle diseases better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | August 4, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $611,151 |
| NIH project number | 5R01AR083233-02 |
| Project ID | NIH-10899638 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with known titin mutations or those experiencing unexplained muscle weakness or myopathies.
✕Less likely to help
Patients without muscle-related conditions or those not carrying titin mutations may not benefit from this research.
What this research studies
This research investigates the role of titin, a key protein in skeletal muscle, in regulating muscle stiffness and mechanosensing when muscles are activated. By using mouse models, the study will explore how specific segments of titin interact with other muscle components during contraction, which may differ from its behavior in relaxed muscles. The research aims to uncover the mechanisms by which titin contributes to muscle function and how mutations in this protein can lead to muscle diseases.
Why it matters
Potential benefit: If successful, this research could lead to new insights into muscle disorders and potential therapeutic targets for patients with titin-related myopathies.
How similar studies have gone: While the role of titin in muscle function has been studied, this research explores novel aspects of its mechanosensing capabilities, making it a potentially groundbreaking investigation.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Granzier, Henk L. — University of Arizona
- Study coordinator: Granzier, Henk L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.