Understanding how tissues interact during the development of the coronal suture in the skull
Molecular mechanisms of tissue interactions during coronal suture development
This study is looking at how certain tissues work together to help form the coronal suture in the skull, focusing on a protein called Pdgfra that plays a key role in this process, which could help improve treatments for conditions like craniosynostosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10663822 on NIH RePORTER |
What this research studies
This research investigates the interactions between specific tissues during the development of the coronal suture, which is crucial for proper skull formation. The study focuses on the role of a protein called Pdgfra, which is important for craniofacial development and is linked to conditions like craniosynostosis. Researchers will use mouse models to explore how the removal of certain tissues affects suture development and how Pdgfra regulates these processes. By understanding these mechanisms, the research aims to uncover potential pathways that could lead to better treatments for craniofacial abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with craniosynostosis or related craniofacial deformities.
Not a fit: Patients without craniofacial abnormalities or those who do not have a genetic predisposition to such conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with craniosynostosis and other craniofacial abnormalities.
How similar studies have performed: Previous research has shown success in understanding craniofacial development through similar genetic and molecular approaches, indicating that this study builds on established knowledge.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: He, Fenglei — Tulane University of Louisiana
- Study coordinator: He, Fenglei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.