Understanding how tissues function by mapping their molecular and cellular dynamics
Molecular profiling of global tissue dynamics at sub cellular resolution
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10907018
This study is exploring how different cells in our tissues work together and interact with each other, using cutting-edge technology to help us see these interactions in real-time, which could improve our understanding of how our bodies function.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10907018 on ClinicalTrials.gov |
What this research studies
This research investigates the dynamic interactions within tissues by utilizing advanced technologies like single-cell RNA sequencing and multiplexed tissue imaging. It aims to create a comprehensive platform that links the structure of tissues with their functional behaviors, allowing for real-time observation of how cells and molecules interact. By developing a method called Molecular profiling of Tissue Dynamics (MOTID), the project seeks to provide insights applicable across various tissue types and models, enhancing our understanding of multicellular communities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that affect tissue dynamics, such as cardiac infarction or other diseases involving cellular migration and interaction.
Not a fit: Patients with stable, non-dynamic tissue conditions may not receive significant benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding tissue function, potentially improving treatments for various diseases.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques to study tissue dynamics, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, MILES A — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: MILLER, MILES A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.