Understanding how tissue structure affects its function and failure
Official title: Integrate Data-Driven Modeling and Multi-scale Measures Towards Tissue Function
Funded at Lehigh University · NIH-11042527 · Data updated 2026-11-12
This study is looking at how cells and the collagen in our tissues work together, especially to understand how these interactions might lead to problems like aneurysms, so we can create better ways to treat patients and keep their tissues healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lehigh University NIH-funded |
| Lab location | 1 site (Bethlehem, United States) |
| Project start | September 20, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $323,536 |
| NIH project number | 1R01GM157589-01 |
| Project ID | NIH-11042527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for aneurysms or those experiencing tissue degeneration.
✕Less likely to help
Patients with stable tissue conditions unrelated to the study's focus may not receive any benefit from this research.
What this research studies
This research investigates the complex interactions between cell signaling and the collagen matrix in human tissues, focusing on how these factors contribute to tissue function and potential failure. By developing a new bio-mathematical framework, the team aims to integrate data-driven modeling with experimental measurements to better understand tissue behavior at multiple scales. The ultimate goal is to create a digital twin model that can predict tissue degeneration related to aneurysm growth, which could lead to improved treatment strategies. Patients may benefit from insights gained about tissue health and the mechanisms behind tissue-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to better predictive models for tissue degeneration, improving treatment options for patients with conditions like aneurysms.
How similar studies have gone: While the integration of data-driven modeling and experimental approaches is a growing field, this specific application to tissue degeneration and aneurysm growth is relatively novel.
Where this research is happening
-
Lehigh University
Bethlehem, United States Active
Researchers
- Principal investigator: Yu, Yue — Lehigh University
- Study coordinator: Yu, Yue
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.