Understanding how tissue structure affects its function and failure
Integrate Data-Driven Modeling and Multi-scale Measures Towards Tissue Function
['FUNDING_R01'] · LEHIGH UNIVERSITY · NIH-11042527
This study is looking at how cells and the collagen in our tissues work together, especially to understand how these interactions might lead to problems like aneurysms, so we can create better ways to treat patients and keep their tissues healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LEHIGH UNIVERSITY (nih funded) |
| Locations | 1 site (BETHLEHEM, UNITED STATES) |
| Trial ID | NIH-11042527 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between cell signaling and the collagen matrix in human tissues, focusing on how these factors contribute to tissue function and potential failure. By developing a new bio-mathematical framework, the team aims to integrate data-driven modeling with experimental measurements to better understand tissue behavior at multiple scales. The ultimate goal is to create a digital twin model that can predict tissue degeneration related to aneurysm growth, which could lead to improved treatment strategies. Patients may benefit from insights gained about tissue health and the mechanisms behind tissue-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for aneurysms or those experiencing tissue degeneration.
Not a fit: Patients with stable tissue conditions unrelated to the study's focus may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictive models for tissue degeneration, improving treatment options for patients with conditions like aneurysms.
How similar studies have performed: While the integration of data-driven modeling and experimental approaches is a growing field, this specific application to tissue degeneration and aneurysm growth is relatively novel.
Where this research is happening
BETHLEHEM, UNITED STATES
- LEHIGH UNIVERSITY — BETHLEHEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YU, YUE — LEHIGH UNIVERSITY
- Study coordinator: YU, YUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.