Understanding how tissue structure affects blood vessel formation
Matrix biophysics and pericyte mechanobiology in (patho)physiological angiogenesis
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11078309
This study is looking at how the structure around cells affects special cells called pericytes that help grow new blood vessels, with the goal of finding better ways to help heal tissues in conditions like heart disease, cancer, and chronic wounds.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11078309 on ClinicalTrials.gov |
What this research studies
This research investigates how the physical properties of the extracellular matrix influence the behavior of pericytes, which are crucial for the formation of new blood vessels. By studying these interactions in a controlled laboratory setting, the researchers aim to develop new strategies for promoting vascularization in tissues affected by various diseases. The project focuses on creating three-dimensional environments that mimic natural tissue to better understand how pericytes can be guided to support blood vessel growth. This could lead to innovative treatments for conditions like heart disease, cancer, and chronic wounds.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from conditions such as myocardial infarction, atherosclerosis, or diabetic wounds.
Not a fit: Patients with conditions unrelated to microvascular diseases or those who do not require vascularization therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advanced therapies that improve healing and recovery for patients with microvascular diseases.
How similar studies have performed: Other research has shown promising results in using similar approaches to enhance blood vessel formation, indicating potential for success in this area.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PHILLIPPI, JULIE A — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: PHILLIPPI, JULIE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.