Understanding how tissue shapes develop during growth
Tissue morphogenesis: From signals to forces
This study looks at how cells work together to shape tissues as they grow, focusing on a special protein that helps them pull and push, which could help us understand and improve treatments for conditions related to tissue development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-11000266 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells generate forces to shape tissues during development. It focuses on the role of actomyosin, a protein complex, in regulating these forces and how they influence cell behavior and tissue formation. By studying the dynamic interactions of cells in model organisms like Drosophila, the research aims to uncover the signaling pathways and mechanical connections that drive tissue morphogenesis. Patients may benefit from insights gained into congenital abnormalities and tissue development processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with congenital abnormalities or those interested in developmental biology.
Not a fit: Patients with conditions unrelated to tissue development or congenital defects may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating birth defects and congenital abnormalities.
How similar studies have performed: Other research has shown success in understanding cellular mechanics and signaling in tissue development, indicating that this approach has a solid foundation.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Martin, Adam Christopher — Massachusetts Institute of Technology
- Study coordinator: Martin, Adam Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.