Understanding how tissue scarring occurs after reduced blood flow
Molecular control of ischemia-induced tissue fibrosis
This study is looking at how certain immune cells called macrophages help cause scarring in tissues when blood flow is low, which can happen in heart conditions, and it hopes to find new ways to treat these issues for patients with heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10630129 on NIH RePORTER |
What this research studies
This research investigates the role of immune cells, specifically macrophages, in the development of tissue scarring caused by chronic reduced blood flow, known as ischemia. By examining how these cells contribute to the production of fibrotic tissue, the study aims to identify specific signaling pathways that could be targeted for therapeutic intervention. The researchers will utilize both in vivo and in vitro methods, including genetic manipulation and RNA sequencing, to explore the mechanisms behind fibrosis in cardiovascular diseases. Patients may benefit from insights gained that could lead to new treatments for conditions like coronary artery disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from ischemic heart disease or related cardiovascular conditions that involve tissue fibrosis.
Not a fit: Patients with non-cardiovascular conditions or those without any signs of ischemic heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce tissue scarring and improve heart function in patients with ischemic heart disease.
How similar studies have performed: Previous research has shown promising results in targeting macrophage signaling pathways to reduce fibrosis, indicating that this approach may be effective.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Yu, Jun — Temple Univ of the Commonwealth
- Study coordinator: Yu, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.