Understanding how tiny vesicles spread misfolded tau protein in Alzheimer's disease
Molecular characterization of extracellular vesicles for the spread of misfolded tau protein
['FUNDING_R01'] · MAYO CLINIC JACKSONVILLE · NIH-11080207
This study is looking at tiny particles in the brain that might help spread a harmful protein linked to Alzheimer's disease, and it's for anyone interested in understanding how this disease works and finding new ways to treat it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-11080207 on ClinicalTrials.gov |
What this research studies
This research investigates the role of extracellular vesicles (EVs) in the spread of misfolded tau protein, which is linked to Alzheimer's disease. By isolating and analyzing these vesicles from human brain samples, the study aims to uncover the molecular mechanisms that allow these vesicles to transfer tau pathology between neurons. The researchers will use advanced techniques, including proteomic profiling and machine learning, to differentiate between vesicles from Alzheimer's patients and healthy individuals. This work could lead to a better understanding of how tau aggregates form and spread, potentially informing new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those exhibiting early symptoms of cognitive decline.
Not a fit: Patients with other forms of dementia not related to tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of Alzheimer's disease and pave the way for innovative treatments that target tau pathology.
How similar studies have performed: Previous research has shown promising results in understanding the role of extracellular vesicles in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IKEZU, TSUNEYA — MAYO CLINIC JACKSONVILLE
- Study coordinator: IKEZU, TSUNEYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease brain