Understanding how tiny vesicles in the brain affect Alzheimer's disease
Fundamental biology of neuronal extracellular vesicles
This study is looking at tiny particles called extracellular vesicles that carry important proteins related to Alzheimer's disease, to see how they might help or hurt the progression of the condition, especially as people age or experience stress, with the goal of finding new ways to detect and treat Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project ID | NIH-10795735 on NIH RePORTER |
What this research studies
This research investigates the role of extracellular vesicles (EVs) in Alzheimer's disease, focusing on how these vesicles carry proteins like amyloid beta and tau that may contribute to the disease's progression. The study aims to understand how factors such as age and cellular stress influence the release of EVs from neurons and their potential role in both promoting and mitigating Alzheimer's pathology. By analyzing EVs from blood and cerebrospinal fluid, researchers hope to identify biomarkers for Alzheimer's and explore therapeutic strategies that could enhance the beneficial effects of these vesicles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk due to age or genetic factors.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools and treatments for Alzheimer's disease, improving patient outcomes.
How similar studies have performed: While the role of extracellular vesicles in Alzheimer's is a relatively new area of investigation, preliminary studies suggest promising avenues for understanding and treating the disease.
Where this research is happening
Piscataway, United States
- Rutgers, the State Univ of N.j. — Piscataway, United States (Active)
Researchers
- Principal investigator: Barr, Maureen M — Rutgers, the State Univ of N.j.
- Study coordinator: Barr, Maureen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.