Understanding how tiny vesicles in the body can signal and affect cancer behavior.
Integrative, multi-parametric characterization of the EV surface protein and nucleic acid landscape by nano-flow and sorting cytometry
This study is looking at tiny particles released by cancer cells to see how they share information that might affect your treatment and immune response, with the hope of finding better ways to diagnose and personalize care for cancer patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10489380 on NIH RePORTER |
What this research studies
This research investigates the role of extracellular vesicles (EVs) in conveying biological information related to cancer. By isolating and analyzing the RNA, proteins, and other components of EVs, the study aims to understand how these vesicles influence gene expression and immune responses in cancer patients. The research employs advanced sorting and profiling techniques to improve the detection and characterization of EVs, which could lead to better diagnostic and prognostic tools for cancer. Patients may benefit from insights into how their tumors communicate and evolve, potentially leading to more personalized treatment approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with various types of cancer who are interested in understanding the molecular mechanisms of their disease.
Not a fit: Patients with non-cancerous conditions or those not producing detectable levels of extracellular vesicles may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for cancer patients.
How similar studies have performed: Other research has shown promising results in using extracellular vesicles as biomarkers for disease, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Ghiran, Ionita Calin — Beth Israel Deaconess Medical Center
- Study coordinator: Ghiran, Ionita Calin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.