Understanding how tiny vesicles from our cells help fight bacterial infections.
The Function of Host-derived Extracellular Vesicles in Trafficking of Bacterial Antigens to Stimulate the Antibacterial Immune Response
This study is looking at tiny particles that help your immune system fight off infections from bacteria like Salmonella, and it hopes to find new ways to boost your body's defenses against these types of illnesses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11073095 on NIH RePORTER |
What this research studies
This research investigates how small vesicles, known as extracellular vesicles (EVs), play a role in the immune response against bacterial infections, specifically those caused by Salmonella enterica. The study focuses on how these vesicles can carry bacterial antigens to immune cells, stimulating a stronger immune response. By examining the mechanisms of how these vesicles function, the research aims to uncover new ways to enhance the body's ability to fight off these infections. Patients may benefit from insights that could lead to new preventive measures or treatments for bacterial diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of severe bacterial infections, particularly those caused by Salmonella.
Not a fit: Patients with viral infections or those not at risk for bacterial diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective vaccines or therapies against serious bacterial infections.
How similar studies have performed: Other research has shown promise in using extracellular vesicles to enhance immune responses, indicating potential for success in this approach.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Ferraro, Mariola Jadwiga — University of Florida
- Study coordinator: Ferraro, Mariola Jadwiga
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.