Understanding how tiny vesicles communicate between cells in the body
Advanced molecular engineering approach for understanding extracellular vesicle in vivo trafficking mechanism
['FUNDING_OTHER'] · UNIVERSITY OF FLORIDA · NIH-11011896
This study is looking at tiny particles called extracellular vesicles that help cells talk to each other and how they can move across barriers in the body, like the blood-brain barrier, to find new ways to treat diseases.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-11011896 on ClinicalTrials.gov |
What this research studies
This research investigates the role of extracellular vesicles (EVs) in cell communication and their ability to cross biological barriers, such as the blood-brain barrier. By employing advanced molecular engineering techniques, the study aims to identify the specific surface receptors on EVs that facilitate their targeting and accumulation in various tissues. The research includes developing innovative technologies like CRISPR imaging and artificial intelligence models to enhance the understanding of EV behavior in vivo. Ultimately, this work seeks to bridge the gap between laboratory findings and clinical applications, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that require targeted drug delivery across the blood-brain barrier or those involved in studies of cell communication.
Not a fit: Patients with conditions unrelated to cell communication or those not requiring targeted therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved drug delivery methods and therapies for conditions affecting the brain and other tissues.
How similar studies have performed: Other research has shown promise in using similar molecular engineering approaches to enhance drug delivery and therapeutic efficacy, indicating a potential for success in this area.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HE, MEI — UNIVERSITY OF FLORIDA
- Study coordinator: HE, MEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.