Understanding how tiny RNAs control genes and cell organization
Regulation of gene expression and genome organization by small RNAs
This project explores how tiny molecules called small RNAs help control our genes, which is important for understanding human development and diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11088870 on NIH RePORTER |
What this research studies
Our bodies rely on small RNAs to manage how genes are turned on and off, a process called RNA silencing. When this process doesn't work correctly, it can lead to health problems, including birth defects and cancers. We are using a small worm, C. elegans, as a model to carefully watch how these small RNAs and their helper proteins organize themselves within cells. By studying how these components assemble and function, we hope to uncover the basic rules that govern gene expression in all living things, including humans.
Who could benefit from this research
Good fit: Patients with conditions related to gene expression errors, such as specific cancers or congenital abnormalities, might eventually benefit from this basic research.
Not a fit: Patients seeking immediate new treatments or direct clinical interventions would not directly benefit from this early-stage basic science.
Why it matters
Potential benefit: This foundational knowledge could lead to new ways to understand and potentially treat diseases where gene control goes wrong, such as certain cancers and birth defects.
How similar studies have performed: The fundamental role of RNA silencing in gene regulation is well-established, and previous work has shown its importance across many species.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Phillips, Carolyn Marie — University of Southern California
- Study coordinator: Phillips, Carolyn Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.