Understanding how tiny RNAs control genes across generations
Mechanism and function of small RNAs in development and gene silencing in the germline
This research explores how very small RNA molecules guide gene activity and inheritance, which is important for understanding development and diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-11077192 on NIH RePORTER |
What this research studies
Our bodies contain tiny RNA molecules, 20-30 nucleotides long, that play a big role in nearly all aspects of development and disease, from fertility to cancer. These small RNAs work with special proteins to either turn genes off or on, influencing how our cells function. This project uses a tiny worm, C. elegans, to uncover the exact ways these small RNAs regulate gene expression and how some of them can even be passed down through generations. By understanding these fundamental processes, we hope to gain insights into how genes are controlled in human health and disease.
Who could benefit from this research
Good fit: This foundational research does not directly involve human participants, but its findings could eventually benefit patients with conditions related to gene regulation, such as certain cancers or fertility issues.
Not a fit: Patients seeking immediate clinical treatments or direct participation in human trials would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could provide foundational knowledge about gene regulation and inheritance, potentially leading to new ways to understand and address conditions like cancer and infertility.
How similar studies have performed: Other studies have identified roles for small RNAs in gene regulation, and this project builds upon existing knowledge to explore the mechanisms in more detail.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Montgomery, Taiowa Akoni — Colorado State University
- Study coordinator: Montgomery, Taiowa Akoni
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.