Understanding how tiny molecules worsen hardening of the arteries
Mechanisms by which Small Nucleolar RNAs Exacerbate Atherosclerosis
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11109440
This project looks for new ways to reduce hardening of the arteries (atherosclerosis) by targeting tiny molecules, aiming to avoid side effects on the immune system.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11109440 on ClinicalTrials.gov |
What this research studies
Hardening of the arteries, called atherosclerosis, is made worse by harmful molecules known as reactive oxygen species (ROS). Current methods to lower these ROS can unfortunately make people more vulnerable to infections. Our team is exploring a new approach that focuses on small, noncoding molecules called snoRNAs, which appear to increase ROS levels. We hope to find a way to reduce atherosclerosis by controlling these snoRNAs, without weakening the body's ability to fight off illness.
Who could benefit from this research
Good fit: Future patients with atherosclerosis, especially those who might benefit from treatments that do not compromise their immune defenses, are the target beneficiaries of this research.
Not a fit: Patients without atherosclerosis or those whose condition is not related to reactive oxygen species may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for atherosclerosis that are more effective and safer for the immune system.
How similar studies have performed: This project explores novel mechanisms involving snoRNAs to constrain atherosclerosis, building on preliminary findings in animal models.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FREEDMAN, NEIL J. — DUKE UNIVERSITY
- Study coordinator: FREEDMAN, NEIL J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.