Understanding how tiny molecules control inflammation as we age
MicroRNA regulation of chronic inflammation during aging
['FUNDING_R01'] · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · NIH-11076658
This work explores how small genetic regulators called microRNAs influence chronic inflammation, often called 'inflammaging,' which contributes to many health issues as people get older.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11076658 on ClinicalTrials.gov |
What this research studies
Chronic inflammation, or 'inflammaging,' is a significant factor in many age-related conditions like diabetes, cancer, and frailty. We are looking into how specific microRNAs, which are tiny molecules that help control our genes, play a role in these inflammatory processes. Our focus is on how these microRNAs affect immune cells, particularly T cells, in older individuals. By understanding these mechanisms, we hope to uncover new ways to manage or prevent age-related inflammatory diseases.
Who could benefit from this research
Good fit: This foundational research is relevant to older adults experiencing or at risk for age-related chronic inflammatory conditions.
Not a fit: Patients not experiencing age-related chronic inflammation or those with acute, non-age-related inflammatory conditions may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or strategies to reduce chronic inflammation and improve health outcomes for older adults.
How similar studies have performed: Previous studies, including our own, have shown that specific microRNAs are critical in regulating inflammation and influencing lifespan in models of chronic inflammation.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: O'CONNELL, RYAN M — UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- Study coordinator: O'CONNELL, RYAN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.