Understanding how tiny molecules called microRNAs are controlled in the body, especially in cancers
Molecular mechanisms for regulating microRNA levels in metazoans
This project explores how the levels of important tiny molecules called microRNAs are managed in our bodies, which could help us understand diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11124797 on NIH RePORTER |
What this research studies
Our genes are regulated by small molecules called microRNAs, and when these microRNAs are out of balance, it can contribute to diseases such as cancer. This work aims to uncover the precise ways our bodies control the amount of these microRNAs, focusing on two main processes. One process involves how certain target RNAs can cause microRNAs to break down, and we want to find more of these triggers. The other area looks at how a key enzyme called Dicer helps create mature microRNAs, and how its lower levels might affect different microRNAs in cancer.
Who could benefit from this research
Good fit: Patients with cancers or other diseases linked to microRNA imbalances may find this foundational research relevant to future treatment options.
Not a fit: Patients seeking immediate clinical trials or direct treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new fundamental insights into how microRNAs contribute to cancer and other diseases, potentially leading to new ways to develop treatments.
How similar studies have performed: This project aims to address current knowledge gaps regarding microRNA regulation, suggesting it explores novel aspects of these mechanisms.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Xie, Mingyi — University of Florida
- Study coordinator: Xie, Mingyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.