Understanding how tiny molecules affect the body's reaction to medical implants
Investigate the mechanisms underlying microRNA-146a activity in regulation of foreign body response to biomaterials
This research aims to understand why the body sometimes rejects medical implants, focusing on how small molecules called microRNAs play a role.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project ID | NIH-11090376 on NIH RePORTER |
What this research studies
When medical devices or implants are placed in the body, they can sometimes trigger a 'foreign body response,' which is a type of chronic inflammation. This response can lead to the implant failing, which can be harmful to patients. Our goal is to uncover the specific molecular steps that cause this reaction, especially looking at how certain microRNAs influence the process. By understanding these steps, we hope to find new ways to prevent or reduce this unwanted response, helping implants last longer and work better for you.
Who could benefit from this research
Good fit: This foundational research is relevant to patients who have medical implants, or those who may need them in the future, as it seeks to improve their long-term success.
Not a fit: Patients without medical implants or those not considering them would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or improved implant designs that prevent the body from rejecting medical devices, making implants safer and more effective for patients.
How similar studies have performed: While the specific role of microRNA-146a in foreign body response is still being explored, other studies have shown that microRNAs are important regulators in inflammation and cell processes.
Where this research is happening
College Park, United States
- Univ of Maryland, College Park — College Park, United States (Active)
Researchers
- Principal investigator: Rahaman, Shaik O — Univ of Maryland, College Park
- Study coordinator: Rahaman, Shaik O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.