Understanding how tiny cell structures called actin filaments keep our cells healthy
Elucidating the roles for discrete actin filaments in maintenance of organelle and cellular homeostasis
['FUNDING_OTHER'] · THOMAS JEFFERSON UNIVERSITY · NIH-11137593
This work explores how specific tiny fibers within our cells, called actin filaments, help maintain the health and function of important cell parts like the ER and mitochondria.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11137593 on ClinicalTrials.gov |
What this research studies
Our cells contain a network of tiny fibers, including actin filaments, that are crucial for how different parts of the cell move, communicate, and stay healthy. While we know a lot about how some of these fibers work, the specific roles of certain actin filaments in managing the endoplasmic reticulum (ER) and mitochondria—two vital cell components—are not well understood. This project focuses on two distinct types of actin filaments: one that forms around the ER and another that forms around mitochondria when they are not working properly. By learning how these specific actin structures are built and how they affect cell health, we hope to uncover new insights into fundamental cell processes.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on this work might seek individuals with conditions related to cellular dysfunction or organelle health.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this basic understanding could eventually lead to new ways to address diseases linked to problems with cell organelles and their internal structures.
How similar studies have performed: While the general roles of actin filaments are known, this project explores novel, distinct pools of actin and their specific functions in organelle dynamics, making this a relatively new area of focus.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAKRABARTI, RAJARSHI — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: CHAKRABARTI, RAJARSHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.