Understanding how tiny cell parts work to cause diseases
Structural and Functional Studies of Molecular Machines Involved in Chemical Modifications of Macromolecules
This research explores how specific cellular processes go wrong in diseases like cancer and neurodegenerative conditions, aiming to find new ways to help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11124643 on NIH RePORTER |
What this research studies
Our cells rely on complex machinery to make tiny chemical changes to important molecules, which is crucial for everything from how our genes work to how proteins function. When these chemical changes are disrupted, it can lead to serious health problems, including various cancers and diseases affecting the brain and nerves. This project uses advanced techniques to look closely at the structure and function of these cellular machines, especially focusing on two systems called p97 and Vault. By understanding how these systems work normally and what happens when they malfunction due to disease-related changes, we hope to discover new targets for future treatments. Our goal is to develop new strategies to correct these issues and improve patient health.
Who could benefit from this research
Good fit: Patients with neurodegenerative diseases linked to p97 mutations or other conditions involving the studied molecular machines could potentially benefit from future treatments developed from this foundational knowledge.
Not a fit: Patients seeking immediate treatment options may not directly benefit from this basic science research, as it focuses on fundamental mechanisms rather than direct clinical application.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of disease mechanisms, paving the way for new diagnostic tools and targeted therapies for cancers and neurodegenerative diseases.
How similar studies have performed: While the general area of molecular modifications is known, this research focuses on specific systems that are currently poorly understood, suggesting a novel approach to these particular mechanisms.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Zhao, Minglei — University of Chicago
- Study coordinator: Zhao, Minglei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.