Understanding how time affects heart disease recovery
Investigating the Time-Dependent Reversibility of DCM-Induced Epigenetic, Matrix, and Functional Remodeling
This study is looking at how the timing of treatment can help improve heart health in people with dilated cardiomyopathy (DCM), a heart condition that can run in families, by using a special mouse model to see if and when changes in the heart can be reversed.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10910216 on NIH RePORTER |
What this research studies
This research investigates dilated cardiomyopathy (DCM), a common inherited heart condition that leads to heart dysfunction and enlargement. The study focuses on how the timing of treatment impacts the ability to reverse changes in heart tissue and genetic material caused by the disease. Using a specialized mouse model, researchers will explore the effects of DCM mutations over time and how they influence heart recovery. The goal is to determine if and when these changes can be reversed, which could lead to better treatment strategies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy or those with a family history of the condition.
Not a fit: Patients with other types of heart disease or those without a genetic predisposition to dilated cardiomyopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options that effectively reverse heart damage in patients with dilated cardiomyopathy.
How similar studies have performed: Previous research has shown promising results in understanding heart disease mechanisms, but this specific approach to studying time-dependent reversibility is relatively novel.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Reichardt, Isabella — University of Washington
- Study coordinator: Reichardt, Isabella
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.