Understanding how Tie2 receptor activation affects blood vessel growth
Official title: Structural Mechanism of Activation and Modulation of Tie2-mediated Angiogenesis
Funded at Fred Hutchinson Cancer Center · NIH-10903539 · Data updated 2026-11-12
This study is looking at how a special protein called the Tie2 receptor helps create new blood vessels, which is important for heart health, and it aims to find ways to improve or control blood vessel growth for people with heart-related issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $44,249 |
| NIH project number | 1F31HL174166-01 |
| Project ID | NIH-10903539 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve abnormal angiogenesis, such as certain cancers or cardiovascular diseases.
✕Less likely to help
Patients with stable cardiovascular health and no history of angiogenesis-related conditions may not receive direct benefits from this research.
What this research studies
This research investigates the structural mechanisms behind the activation of the Tie2 receptor, which plays a crucial role in the formation of new blood vessels, a process known as angiogenesis. By examining how Tie2 interacts with angiopoietin-1, the study aims to uncover the signaling pathways that lead to the proliferation and movement of endothelial cells. The research employs advanced biophysical techniques to analyze the receptor's behavior and its implications for vascular health. Patients may benefit from insights gained into how to enhance or regulate blood vessel growth in various cardiovascular conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases related to abnormal blood vessel growth, such as cancer and cardiovascular disorders.
How similar studies have gone: Previous research has shown promising results in understanding receptor signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Nguyen, Adam — Fred Hutchinson Cancer Center
- Study coordinator: Nguyen, Adam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.