Understanding how TIAM1 influences the development of bone and fat cells from pericytes
TIAM1 dictates lineage commitment in skeletal and soft tissue pericytes
['FUNDING_CAREER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11063836
This study is looking at how a protein called TIAM1 affects certain cells in your body that can turn into either bone or fat, with the goal of finding ways to help heal bones better for people who have trouble with bone repair.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11063836 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific protein, TIAM1, in determining whether human pericytes develop into bone-forming or fat-forming cells. By analyzing pericytes from different tissues, the team aims to understand how these cells can be directed to support bone regeneration. The approach includes advanced techniques like transcriptomic analysis and gene deletion to explore the potential for enhancing bone healing in patients with non-healing bony defects. Patients may benefit from insights that could lead to improved therapies for bone repair and regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that result in non-healing bone defects, such as those with severe arthritis or other skeletal disorders.
Not a fit: Patients with acute bone injuries or those whose conditions do not involve bone regeneration issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with bone healing issues, potentially improving recovery outcomes.
How similar studies have performed: Previous research has shown promise in using mesenchymal stem cells for tissue engineering, but this specific approach focusing on TIAM1 is relatively novel.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HSU, GINNY CHING-YUN — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: HSU, GINNY CHING-YUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.