Understanding how thyroid hormones affect heart health differently in women and men
Official title: Unraveling tissue level regulation of thyroid hormone and its role in sex differences in cardiovascular health
Funded at University of Colorado Denver · NIH-10947796 · Data updated 2026-11-12
This study is looking at how thyroid hormones affect heart health, especially why women might be more at risk for heart failure than men, and it aims to find out how a specific protein helps manage these hormones in the heart to better protect women after heart problems.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $163,344 |
| NIH project number | 1K01HL174689-01 |
| Project ID | NIH-10947796 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have experienced heart-related issues, particularly those with a history of heart attacks or heart failure.
✕Less likely to help
Patients who are not affected by cardiovascular diseases or those who do not have thyroid hormone-related conditions may not benefit from this research.
What this research studies
This research investigates the role of thyroid hormones in cardiovascular health, particularly focusing on how these hormones may contribute to the higher risk of heart failure in women compared to men. The study will explore the regulation of thyroid hormones at the tissue level, specifically examining a protein called type 3 deiodinase (DIO3) that influences thyroid hormone levels in the heart. By using animal models, the research aims to uncover the mechanisms behind sex differences in heart health and how thyroid hormone regulation may protect female hearts after events like heart attacks.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for cardiovascular diseases in women, potentially reducing their risk of heart failure.
How similar studies have gone: Previous research has indicated that understanding sex differences in cardiovascular health can lead to significant advancements in treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Da Silva Teixeira, Silvania — University of Colorado Denver
- Study coordinator: Da Silva Teixeira, Silvania
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.