Understanding how thyroglobulin affects thyroid hormone production
Official title: The Role of Thyroglobulin in Thyroid Hormone Synthesis
Funded at Chapman University · NIH-10975356 · Data updated 2026-11-12
This study is looking into how a substance called thyroglobulin helps make important thyroid hormones that affect growth and metabolism, and it hopes to find new ways to help people, especially children, who have health issues from low hormone levels, like obesity and developmental delays.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chapman University NIH-funded |
| Lab location | 1 site (Orange, United States) |
| Project start | January 19, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $150,832 |
| NIH project number | 5K01DK125448-05 |
| Project ID | NIH-10975356 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with hypothyroidism or those experiencing symptoms related to thyroid hormone deficiencies.
✕Less likely to help
Patients with normal thyroid function or those not affected by thyroid hormone-related conditions may not benefit from this research.
What this research studies
This research investigates the role of thyroglobulin in the synthesis of thyroid hormones, which are crucial for growth and metabolism. It aims to understand how deficiencies in these hormones can lead to various health issues, including obesity and developmental problems in children. By exploring the mechanisms of hormone production regulated by thyroid-stimulating hormone, the research seeks to identify potential new treatments for hypothyroidism. Patients may benefit from insights that could lead to improved management of thyroid-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for thyroid hormone deficiencies, improving health outcomes for affected individuals.
How similar studies have gone: Previous research has shown promising results in understanding thyroid hormone synthesis, but this specific approach focusing on thyroglobulin is relatively novel.
Where this research is happening
-
Chapman University
Orange, United States Active
Researchers
- Principal investigator: Citterio, Cintia E. — Chapman University
- Study coordinator: Citterio, Cintia E.
Related research
Other NIH-funded projects on the same topics.
-
Positive Affect and Asthma in Kids: A New Way to Help Teens Stick to Their Inhalers
A study at Chapman University aims to help children and teens with asthma use their inhaled medications more consistently by using positive psychology approaches.
-
Understanding how infection, activity, genes, and sex affect dementia risk in Native South American groups
This project looks at how infections, exercise, APOE genotype, and biological sex influence cognitive aging and brain changes in two Native South American communities.
-
Oral inhibitors that block nNOS to help melanoma patients
A new oral medicine that blocks an enzyme called nNOS could slow melanoma growth and boost how well immunotherapy works for patients whose disease has spread.
-
A brain-penetrating form of erythropoietin aimed at treating Alzheimer’s disease
They are developing a modified erythropoietin that can enter the brain to protect nerve cells and help people with Alzheimer’s disease.
-
Tracking Indoor Air to Help Kids Quit Smoking
A program that uses IoT air sensors and tele-counseling to help families in low-income communities quit smoking and keep homes smoke-free.
-
How immune cells cause eye scarring and severe dry eye after bone marrow transplant
This project looks at how a type of immune cell called a macrophage leads to scarring, loss of tear-producing cells, and severe dry eye in people who develop ocular graft‑versus‑host disease after an allogeneic bone marrow transplant.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.