Understanding how thiyl radicals function in enzymes and their role in health
Official title: Regulation and maintenance of thiyl radicals in enzyme catalysis and protein degradation
Funded at University of California Santa Barbara · NIH-11136528 · Data updated 2026-11-12
This study is looking at tiny particles called thiyl radicals that help enzymes work but can also cause damage in the body, and by understanding how they behave, we hope to find better treatments for health issues related to stress and enzyme problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Barbara NIH-funded |
| Lab location | 1 site (Santa Barbara, United States) |
| Project start | July 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $354,155 |
| NIH project number | 5R35GM154993-02 |
| Project ID | NIH-11136528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant bacteria, particularly those related to oxidative stress.
✕Less likely to help
Patients with conditions unrelated to enzyme dysfunction or oxidative stress may not benefit from this research.
What this research studies
This research investigates the role of thiyl radicals, which are important cofactors in enzyme catalysis, and how they can also lead to harmful oxidative stress. The project aims to understand how these radicals are generated and maintained within proteins, which could help in developing new antibiotics and therapies. By exploring the structure and function of these radicals, the research seeks to uncover their impact on human health and potential therapeutic applications. Patients may benefit from insights that could lead to improved treatments for conditions related to oxidative stress and enzyme dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antibiotics and therapies targeting enzyme-related diseases.
How similar studies have gone: Other research has shown promise in understanding enzyme catalysis and oxidative stress, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Santa Barbara
Santa Barbara, United States Active
Researchers
- Principal investigator: Greene, Brandon — University of California Santa Barbara
- Study coordinator: Greene, Brandon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.