Understanding how the varicella-zoster virus stays dormant and reactivates
Role of VZV Latency Transcript (VLT) and ORF63 in latency and reactivation
This study is looking into how the chickenpox virus hides in nerve cells and what causes it to wake up and cause shingles, with the goal of finding better ways to prevent and treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10975933 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the varicella-zoster virus (VZV) maintains latency in nerve cells and what triggers its reactivation, leading to conditions like herpes zoster. The study utilizes human trigeminal ganglia and human embryonic stem cell-derived neuron models to explore the role of specific viral RNA transcripts in this process. By identifying the functions of these transcripts, the research aims to develop new strategies to combat herpes zoster and its associated complications.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced herpes zoster or are at risk of reactivation of the varicella-zoster virus.
Not a fit: Patients who have never been infected with varicella-zoster virus or those who do not have a history of herpes zoster may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for herpes zoster, reducing pain and complications for affected patients.
How similar studies have performed: Previous research has shown promise in understanding viral latency and reactivation in other herpesviruses, suggesting that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Kinchington, Paul R. — University of Pittsburgh at Pittsburgh
- Study coordinator: Kinchington, Paul R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.