Understanding how the uterus regenerates during menstruation
Life history of the menstruating uterus
['FUNDING_OTHER'] · HARVARD UNIVERSITY · NIH-10472829
This study is looking at how the uterus heals itself during menstruation by using a special mouse that also has a menstrual cycle, and the goal is to find new ways to help people dealing with issues like endometriosis, infertility, and certain types of cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD UNIVERSITY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10472829 on ClinicalTrials.gov |
What this research studies
This research investigates the unique regenerative capabilities of the uterus, particularly focusing on the endometrium, which undergoes cycles of shedding and repair during menstruation. By studying the common spiny mouse, the only known menstruating rodent, researchers aim to uncover the molecular and cellular mechanisms behind this regeneration. The findings could lead to new treatments for conditions like endometriosis, infertility, and endometrial cancers, which affect many individuals. The project seeks to bridge the gap in understanding menstruation, a process that is poorly represented in traditional animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing conditions related to menstruation, such as endometriosis, infertility, or other uterine pathologies.
Not a fit: Patients who do not menstruate or have undergone surgical removal of the uterus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for reproductive health issues that affect millions of people.
How similar studies have performed: While research on uterine regeneration is ongoing, this specific approach using the spiny mouse is novel and has not been extensively tested in previous studies.
Where this research is happening
CAMBRIDGE, UNITED STATES
- HARVARD UNIVERSITY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCKINLEY, KARA LAVIDGE — HARVARD UNIVERSITY
- Study coordinator: MCKINLEY, KARA LAVIDGE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.