Understanding how the uterus heals and regenerates itself
Official title: Mechanisms Governing Uterine Epithelial Plasticity
Funded at University of Missouri-Columbia · NIH-11094075 · Data updated 2026-11-12
This study is looking at how the uterine lining heals and grows back after menstruation, injury, or childbirth, to help understand what makes it work well or not, which could lead to better treatments for women dealing with infertility or other uterine issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | August 3, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $443,436 |
| NIH project number | 5R01HD112315-03 |
| Project ID | NIH-11094075 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing infertility or conditions affecting the endometrium, such as Asherman’s syndrome.
✕Less likely to help
Patients who do not have issues related to uterine health or fertility may not benefit from this research.
What this research studies
This research investigates the unique ability of the uterine lining to regenerate after menstruation, injury, or childbirth. It aims to uncover the mechanisms that control the differentiation and regeneration of uterine epithelial cells, which are crucial for successful pregnancies. By studying the behavior of stem cell-like cells in the uterus, the research seeks to identify factors that contribute to conditions like infertility and endometrial diseases. The findings could lead to new diagnostic and treatment options for women facing these challenges.
Why it matters
Potential benefit: If successful, this research could improve the diagnosis and treatment of infertility and endometrial diseases in women.
How similar studies have gone: Previous research has shown promise in understanding uterine regeneration, but this study aims to explore novel aspects of epithelial plasticity that have not been fully tested.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Kelleher, Andrew M — University of Missouri-Columbia
- Study coordinator: Kelleher, Andrew M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.