Understanding how the uterus develops and functions
Official title: Molecular Mechanisms Regulating Uterus Development
Funded at University of Missouri-Columbia · NIH-11141570 · Data updated 2026-11-12
This study is looking at how certain genes and body processes affect the uterus, which is important for having a healthy pregnancy, and it aims to find out why some women have trouble getting pregnant or experience pregnancy loss, with hopes that the findings will help create better tests and treatments for these issues.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | July 19, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $649,068 |
| NIH project number | 5R37HD114609-02 |
| Project ID | NIH-11141570 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing infertility or recurrent pregnancy loss, particularly those with uterine disorders.
✕Less likely to help
Patients without uterine disorders or those who are not experiencing infertility or pregnancy loss may not benefit from this research.
What this research studies
This research investigates the genetic and physiological pathways that regulate the development and function of the uterus, which are crucial for successful pregnancy. By focusing on the glands within the uterus, the study aims to uncover the mechanisms that lead to infertility and pregnancy loss. The research utilizes animal models to explore the role of specific transcription factors, such as FOXA2, in uterine gland development and associated disorders. Patients may benefit from insights gained that could lead to new diagnostic and treatment options for uterine-related infertility issues.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for women experiencing infertility and pregnancy loss.
How similar studies have gone: Previous research has shown promise in understanding uterine development and its implications for fertility, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Spencer, Thomas E — University of Missouri-Columbia
- Study coordinator: Spencer, Thomas E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.