Understanding how the urinary tract senses mechanical changes
Molecular mechanisms of mechanosensing in the urinary tract
['FUNDING_OTHER'] · BAYLOR COLLEGE OF MEDICINE · NIH-10907517
This study is looking at how the bladder and urinary system sense changes like stretching and fluid flow, focusing on certain channels that help with this process, to better understand issues that can affect urination.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10907517 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which the urinary tract detects mechanical changes, such as bladder stretch and urethral fluid flow. It focuses on specific ion channels, PIEZO1 and PIEZO2, which are believed to play a crucial role in sensing these mechanical cues. By using advanced techniques like bladder-pressure recordings and electromyography, the study aims to characterize the reflexes involved in urination and how these processes are integrated within the urinary system. The findings could provide insights into the underlying causes of common urinary tract dysfunctions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 40 who experience lower urinary tract symptoms or dysfunction.
Not a fit: Patients under 21 years old or those without urinary tract issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for urinary tract dysfunctions, benefiting many patients who suffer from these conditions.
How similar studies have performed: Previous research has shown promise in understanding mechanosensing in other systems, but this specific investigation into the urinary tract is relatively novel.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARSHALL, KARA L — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: MARSHALL, KARA L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.