Understanding how the urinary microbiome affects recurrent UTIs in postmenopausal women
Defining the dynamics of urobiome structure and function in postmenopausal women and its role in recurrent UTI susceptibility
This study is looking at how the bacteria in the urine of postmenopausal women might affect their chances of getting repeated urinary tract infections, with the hope of finding new ways to help manage these infections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-11136361 on NIH RePORTER |
What this research studies
This research investigates the role of the urinary microbiome, or urobiome, in postmenopausal women who experience recurrent urinary tract infections (rUTIs). By analyzing the composition and function of the urobiome, the study aims to identify specific factors that contribute to rUTI susceptibility. The approach includes advanced techniques to assess how hormonal changes and the urobiome interact, potentially leading to new probiotic therapies. This research seeks to provide insights that could improve management strategies for women suffering from frequent UTIs.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women who have experienced three or more urinary tract infections within the past year.
Not a fit: Patients who are not postmenopausal or those who do not have a history of recurrent urinary tract infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for recurrent UTIs, significantly improving the quality of life for affected women.
How similar studies have performed: While the concept of targeting the urinary microbiome for UTI treatment is emerging, this specific approach is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: De Nisco, Nicole Janell — University of Texas Dallas
- Study coordinator: De Nisco, Nicole Janell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.