Understanding how the upper urinary tract works and its role in kidney health
Official title: Defining the onset and regulation of myogenic upper urinary tract physiology
Funded at Weill Medical Coll of Cornell Univ · NIH-10981966 · Data updated 2026-11-12
This study is looking into how the muscles in the urinary tract work to help kids with conditions like hydronephrosis and vesicoureteral reflux, which can cause kidney problems, so we can find better ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $577,420 |
| NIH project number | 1R01DK133381-01A1 |
| Project ID | NIH-10981966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are experiencing urinary tract issues such as hydronephrosis or vesicoureteral reflux.
✕Less likely to help
Patients who do not have urinary tract disorders or are older than 11 years may not benefit from this research.
What this research studies
This research investigates the mechanisms that regulate the contractions of the upper urinary tract, which are essential for moving waste from the kidneys to the bladder. It focuses on understanding conditions like hydronephrosis and vesicoureteral reflux, which can lead to serious kidney issues in children. By studying the cellular and physiological processes involved, the research aims to identify the causes of impaired urinary outflow and develop potential interventions. The findings could help improve treatment options for children suffering from urinary tract disorders.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of urinary tract conditions in children, potentially preventing kidney damage.
How similar studies have gone: While there has been research on urinary tract physiology, this specific investigation into the mechanisms of upper urinary tract contractions is novel and has not been extensively studied.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Hurtado, Romulo — Weill Medical Coll of Cornell Univ
- Study coordinator: Hurtado, Romulo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.