Understanding how the unfolded protein response affects liver disease
Dysregulation of the unfolded protein response in the pathogenesis of non-alcoholic steatohepatitis
This study is looking at how a protective process in the liver, called the unfolded protein response, is lost in people with non-alcoholic steatohepatitis (NASH), and it aims to find ways to help restore this process to prevent liver damage.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11054379 on NIH RePORTER |
What this research studies
This research investigates the loss of a protective mechanism in the liver known as the unfolded protein response (UPR) in patients with non-alcoholic steatohepatitis (NASH). By using advanced techniques like single-cell RNA sequencing and precision cut liver slices, the researchers aim to uncover the mechanisms behind UPR loss and its role in the development of NASH. The study will involve both mouse models and human liver specimens to explore potential therapeutic targets that could restore UPR function and protect against liver damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who are diagnosed with non-alcoholic steatohepatitis.
Not a fit: Patients with other forms of liver disease, such as alcoholic liver disease or viral hepatitis, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating non-alcoholic steatohepatitis, potentially improving liver health and reducing the need for liver transplants.
How similar studies have performed: Other research has shown promising results in understanding the unfolded protein response in various diseases, suggesting that this approach could yield valuable insights for NASH as well.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sherman, Marc S — Massachusetts General Hospital
- Study coordinator: Sherman, Marc S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.