Understanding how the ubiquitin-proteasome system affects cell processes and disease.
Mechanistic Analysis of the Ubiquitin-Proteasome System
This study is looking at how a system in our cells helps control proteins, which could lead to new treatments for diseases like cancer, and it's for anyone interested in finding better therapies for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11058378 on NIH RePORTER |
What this research studies
This research investigates the ubiquitin-proteasome system (UPS), which plays a crucial role in regulating protein activity, stability, and localization within cells. By studying how ubiquitin is attached to or removed from proteins, the research aims to uncover new insights into cellular processes such as signaling, survival, and division. The project focuses on identifying new substrates of the UPS and understanding the specificity of the enzymes involved, which could lead to novel drug targets for diseases like cancer. Patients may benefit from potential new therapies developed from this research that target the UPS.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cancers or other diseases linked to mutations in the ubiquitin-proteasome system.
Not a fit: Patients with conditions unrelated to the ubiquitin-proteasome system may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases, particularly cancers, by targeting the mechanisms that regulate protein function in cells.
How similar studies have performed: Previous research has shown promise in targeting the ubiquitin-proteasome system for therapeutic purposes, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: King, Randall W — Harvard Medical School
- Study coordinator: King, Randall W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.