Understanding how the Ubiquitin-Proteasome Pathway affects human diseases
Official title: UBIQUITIN-PROTEASOME PATHWAY in HUMAN DISEASE
Funded at University of Connecticut Sch of Med/dnt · NIH-11011382 · Data updated 2026-11-12
This study is looking at how a system in our cells helps break down proteins, which could lead to new treatments for diseases like cancer, especially by focusing on a protein called p53 that often has problems in cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | February 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $528,129 |
| NIH project number | 1R35GM156397-01 |
| Project ID | NIH-11011382 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cancers or other diseases associated with UPP malfunctions.
✕Less likely to help
Patients with conditions unrelated to the Ubiquitin-Proteasome Pathway may not benefit from this research.
What this research studies
This research investigates the Ubiquitin-Proteasome Pathway (UPP), which is crucial for the degradation of proteins in human cells. By examining how UPP components recognize and process their substrates, the research aims to uncover mechanisms that could lead to new treatments for various diseases, including cancer. The team will focus on specific enzymes involved in this pathway, particularly those that regulate the p53 protein, which is often altered in cancer. Through structural and functional characterization, the research seeks to identify potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and other diseases linked to UPP dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the UPP and its role in diseases, indicating that this approach has potential for success.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Bezsonova, Irina — University of Connecticut Sch of Med/dnt
- Study coordinator: Bezsonova, Irina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.