Understanding how the tumor environment affects prostate cancer spread and treatment resistance
Defining Tumor Microenvironmental Mediators of Prostate Cancer Metastasis and Therapy Resistance
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10998222
This study is looking at how certain cells in the area around prostate tumors might affect the spread of advanced prostate cancer and how well treatments work, with the hope of finding new ways to help patients get better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10998222 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the tumor microenvironment in the progression of metastatic prostate cancer and its resistance to therapies. It focuses on cancer-associated fibroblasts (CAFs) and a specific protein called Asporin (ASPN), which may influence how prostate cancer cells spread and respond to treatment. By analyzing these interactions, the research aims to uncover mechanisms that contribute to treatment failure and identify potential new therapeutic targets. Patients may benefit from insights that could lead to more effective treatments for advanced prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with metastatic prostate cancer, particularly those experiencing treatment resistance.
Not a fit: Patients with localized prostate cancer or those who have not yet undergone treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with metastatic prostate cancer, potentially overcoming resistance to current therapies.
How similar studies have performed: Previous research has shown promising results in understanding the tumor microenvironment's role in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HURLEY, PAULA JILL — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: HURLEY, PAULA JILL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.