Understanding how the tumor environment affects cancer treatment resistance
Mechanisms of microenvironment mediated resistance to cancer cell surface targeted therapeutics
This study is looking at how the environment around prostate cancer tumors affects how well treatments work, using a special model to mimic the bone marrow, with the hope of finding better ways to help patients with advanced prostate cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10897095 on NIH RePORTER |
What this research studies
This research investigates how the complex interactions within the tumor microenvironment (TME) influence the effectiveness of cancer therapies, particularly in advanced prostate cancer. By creating a tissue chip model that mimics the bone marrow TME, the study aims to better understand how tumor cells interact with surrounding cells, which can lead to treatment resistance. This innovative approach seeks to improve the pre-screening of new cancer treatments, ensuring they are more effective before reaching clinical trials. The ultimate goal is to enhance treatment outcomes for patients with metastatic castrate-resistant prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with advanced castrate-resistant prostate cancer, particularly those with bone metastases.
Not a fit: Patients with early-stage prostate cancer or those without bone metastases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer therapies and improved survival rates for patients with advanced prostate cancer.
How similar studies have performed: Previous research has shown that incorporating the tumor microenvironment into therapeutic testing can lead to more successful outcomes, indicating that this approach has potential for significant advancements.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Beebe, David J — University of Wisconsin-Madison
- Study coordinator: Beebe, David J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.