Understanding how the TRPM8 ion channel works in health and disease
Molecular Mechanisms and Regulation Networks of TRPM8
This study is looking at a special channel in our cells that helps us feel cold and is connected to issues like cancer, pain, and obesity, to see how it works and how it might help in developing new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-11030726 on NIH RePORTER |
What this research studies
This research investigates the TRPM8 ion channel, which plays a role in sensing cold and is linked to cancer progression, pain, and obesity. The team uses advanced techniques such as NMR studies and whole-cell patch-clamp electrophysiology to explore the molecular mechanisms of this channel. By understanding how TRPM8 responds to various stimuli, including cold temperatures and menthol, the research aims to uncover its potential for therapeutic interventions. This interdisciplinary approach combines biophysical, structural, and computational methods to provide a comprehensive understanding of TRPM8's function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from obesity, chronic pain, or certain types of cancer.
Not a fit: Patients who do not have conditions related to pain, obesity, or cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for pain management and obesity treatment.
How similar studies have performed: Previous research has shown promise in targeting ion channels for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Van Horn, Wade D. — Arizona State University-Tempe Campus
- Study coordinator: Van Horn, Wade D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.