Understanding how the TRPA1 receptor affects pain and inflammation
Molecular mechanisms of TRPA1 regulation
This study is looking at a special part of our body that helps us feel pain and deal with inflammation, to better understand how it works and what goes wrong in conditions like chronic pain and asthma, which could help find new ways to manage these issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11076196 on NIH RePORTER |
What this research studies
This research investigates the TRPA1 receptor, which plays a crucial role in pain perception and inflammation in the body. By examining how this receptor is regulated and how it becomes dysregulated in conditions like chronic pain and asthma, the study aims to uncover the molecular mechanisms behind these processes. The research utilizes advanced techniques to analyze the receptor's structure and function, focusing on how it responds to various chemical signals and inflammatory cues. This could lead to new insights into managing pain and inflammatory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic pain conditions or asthma, particularly those who may have a genetic predisposition to TRPA1 dysregulation.
Not a fit: Patients with acute pain that is not related to chronic conditions or those without any inflammatory diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic pain and inflammatory conditions, improving the quality of life for many patients.
How similar studies have performed: Previous research has shown that understanding the molecular mechanisms of ion channels like TRPA1 can lead to significant advancements in pain management and treatment of inflammatory diseases.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Paulsen, Candice Elaine — Yale University
- Study coordinator: Paulsen, Candice Elaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.