Understanding how the Toxoplasma parasite replicates and invades host cells
Official title: Assembly of the Toxoplasma cortical cytoskeleton
Funded at Boston College · NIH-11103386 · Data updated 2026-11-12
This study is looking at how the Toxoplasma gondii parasite grows inside our cells, which can help us understand how it causes problems for people, and it might lead to new ways to treat infections caused by this parasite.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston College NIH-funded |
| Lab location | 1 site (Chestnut Hill, United States) |
| Project start | June 4, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $193,750 |
| NIH project number | 5R21AI180525-02 |
| Project ID | NIH-11103386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals infected with Toxoplasma gondii, particularly those with compromised immune systems, such as patients with HIV/AIDS.
✕Less likely to help
Patients who are not infected with Toxoplasma gondii or those with healthy immune systems may not benefit from this research.
What this research studies
This research investigates the unique way the Toxoplasma gondii parasite replicates within host cells, focusing on its specialized cytoskeleton that plays a crucial role in its life cycle. The study aims to uncover the mechanisms behind the parasite's ability to invade and replicate quickly, which leads to tissue damage in infected individuals. Using advanced microscopy techniques, researchers will explore the early stages of the parasite's division process to gain insights into its biology and potential vulnerabilities. This knowledge could inform the development of new treatments for infections caused by this opportunistic parasite.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Toxoplasma infections, potentially improving outcomes for affected patients.
How similar studies have gone: While the specific approach of this research is novel, previous studies have successfully identified mechanisms of parasite replication and invasion, indicating potential for meaningful advancements.
Where this research is happening
-
Boston College
Chestnut Hill, United States Active
Researchers
- Principal investigator: Engelberg, Klemens — Boston College
- Study coordinator: Engelberg, Klemens
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.