Understanding how the surrounding tissue affects breast cancer growth
Leveraging the metastatic tumor stroma to limit breast cancer progression
This study is looking at how the supportive tissue around breast cancer cells affects the growth of the cancer and the body's immune response, with the goal of finding new ways to treat metastatic breast cancer and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11053602 on NIH RePORTER |
What this research studies
This research investigates the role of the tumor stroma, the supportive tissue surrounding breast cancer cells, in the progression of metastatic breast cancer. It aims to identify how different cell types within the stroma, such as fibroblasts and adipocytes, contribute to tumor growth and immune response. By focusing on the interactions between tumor cells and their surrounding environment, the study seeks to develop new therapeutic strategies that target these stromal components to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic breast cancer, particularly those with bone metastasis.
Not a fit: Patients with localized breast cancer who have not yet experienced metastasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for metastatic breast cancer by targeting the tumor stroma.
How similar studies have performed: Previous research has shown promising results in targeting the tumor microenvironment in other cancers, indicating potential for success in this novel approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Stewart, Sheila a — Washington University
- Study coordinator: Stewart, Sheila a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.