Understanding how the surrounding tissue affects breast cancer development
Modeling the role and regulation of reactive stroma in breast ductal carcinoma microinvasions
This study is looking at how the supportive tissue around breast cancer cells affects the growth of a specific type of early-stage breast cancer called ductal carcinoma in situ (DCIS), with the hope of finding new ways to prevent and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10914051 on NIH RePORTER |
What this research studies
This research investigates the role of reactive stroma, the supportive tissue around breast cancer cells, in the progression of ductal carcinoma in situ (DCIS). By combining experimental studies with advanced computational models, the team aims to explore how changes in the tissue environment influence cancer cell behavior and the potential for microinvasion. The study will analyze tumor samples and use three-dimensional cultures to better understand the interactions between cancer cells and their surrounding stroma. The ultimate goal is to identify new molecular and physical markers that could lead to improved prevention and treatment strategies for breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ductal carcinoma in situ (DCIS) or those at high risk for developing breast cancer.
Not a fit: Patients with advanced breast cancer or those not diagnosed with DCIS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment options for patients with breast cancer.
How similar studies have performed: Previous research has shown promise in understanding the tumor microenvironment in breast cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Rejniak, Katarzyna Anna — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Rejniak, Katarzyna Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.