Understanding how the surrounding tissue affects breast cancer development
Official title: Stromal contributions to breast carcinogenesis
Funded at University of Florida · NIH-10880612 · Data updated 2026-11-12
This study is looking at how the supportive tissue around breast cells might play a part in the early development of breast cancer, especially in people with benign breast conditions or high breast density, to help us understand the risks better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | July 3, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $657,613 |
| NIH project number | 5R01CA277817-02 |
| Project ID | NIH-10880612 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women with benign breast disease or those with high mammographic breast density.
✕Less likely to help
Patients without benign breast disease or low mammographic breast density may not benefit from this research.
What this research studies
This research investigates the role of the stroma, the supportive tissue surrounding breast cells, in the early stages of breast cancer development. By analyzing data and biopsy samples from large health studies, the research aims to uncover how changes in the stroma contribute to benign breast disease and high breast density, both of which are linked to increased breast cancer risk. An interdisciplinary team will employ advanced techniques to explore these relationships and identify potential molecular mechanisms involved in breast carcinogenesis.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early detection and prevention of breast cancer.
How similar studies have gone: While the role of stroma in advanced breast cancer has been studied, this investigation into its early contributions to carcinogenesis is relatively novel.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Yaghjyan, Lusine — University of Florida
- Study coordinator: Yaghjyan, Lusine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.