Understanding how the structure of tissue affects cell behavior and healing.
Official title: Regional extracellular matrix remodeling: multiscale imaging and mechanics.
Funded at University of Wisconsin-Madison · NIH-11021447 · Data updated 2026-11-12
This study is looking at how the structure of the material around our cells affects tissue health and healing, which could help us find better ways to treat injuries and diseases like fibrosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $367,105 |
| NIH project number | 1R35GM156973-01 |
| Project ID | NIH-11021447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from conditions that involve tissue remodeling, such as fibrosis or chronic wounds.
✕Less likely to help
Patients with acute injuries that do not involve ECM remodeling or those with conditions unrelated to tissue structure may not benefit from this research.
What this research studies
This research investigates the relationship between cells and their surrounding extracellular matrix (ECM), which is crucial for tissue health and healing. It aims to understand how the geometry and structure of the ECM vary across different regions and how these variations influence the tissue's ability to bear loads. By employing advanced imaging techniques, the study seeks to capture the remodeling of the ECM at multiple scales, providing insights into how diseases like fibrosis develop and progress. This knowledge could lead to improved strategies for treating injuries and diseases that disrupt normal tissue function.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for conditions related to tissue damage and fibrosis, enhancing healing and recovery.
How similar studies have gone: Previous research has shown promising results in understanding ECM dynamics, suggesting that this approach could yield significant insights into tissue health.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Witzenburg, Colleen M — University of Wisconsin-Madison
- Study coordinator: Witzenburg, Colleen M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.