Understanding how the structure of the cell nucleus is formed during early mammalian development
Establishment and visualization of nuclear architecture at the onset of mammalian development
This study is looking at how the DNA inside a cell's nucleus is arranged right after fertilization in mammals, which is important for healthy development and can help us understand genetic diseases.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Helmholtz Zentrum Muenchen - Gmbh NIH-funded |
| Lab location | 1 site (Neuherberg, Germany) |
| Project ID | NIH-10704049 on NIH RePORTER |
What this research studies
This research investigates the organization of the cell nucleus at the very beginning of mammalian development, focusing on how DNA is folded and structured within the nucleus. By using advanced visualization techniques, the study aims to observe the formation of nuclear architecture in real-time after fertilization. Understanding these processes is crucial as they can influence gene expression and cellular identity, which are vital for proper development. The research also explores how disruptions in nuclear organization can lead to genetic diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders linked to nuclear architecture or those interested in the early stages of mammalian development.
Not a fit: Patients with fully developed conditions unrelated to nuclear organization or those outside the scope of mammalian development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into genetic diseases and developmental disorders by improving our understanding of nuclear organization.
How similar studies have performed: While the specific approach of real-time visualization of nuclear architecture is novel, related research has shown that understanding nuclear organization can significantly impact our knowledge of genetic diseases.
Where this research is happening
Neuherberg, Germany
- Helmholtz Zentrum Muenchen - Gmbh — Neuherberg, Germany (Active)
Researchers
- Principal investigator: Torres Padilla, Maria Elena — Helmholtz Zentrum Muenchen - Gmbh
- Study coordinator: Torres Padilla, Maria Elena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.