Understanding how the structure of rod cells affects vision in low light
Rod outer segment structure: determinants and its effect on the photon response
This study looks at how certain proteins help keep the parts of our eye that are important for seeing in low light healthy, and it’s for anyone interested in understanding how problems with these proteins might lead to vision loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10650776 on NIH RePORTER |
What this research studies
This research investigates the structure of rod outer segments in retinal cells, which are crucial for vision in dim light. It focuses on the role of specific proteins, peripherin-2 and rom1, in maintaining the integrity of these structures. By manipulating the expression levels of these proteins in mutant mice, the study aims to observe changes in disk size and structure using advanced imaging techniques. This could provide insights into how disruptions in these proteins lead to vision loss and potential strategies for intervention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic mutations affecting retinal structure or function, particularly those at risk for retinal degeneration.
Not a fit: Patients with retinal conditions unrelated to rod outer segment structure or those with advanced stages of retinal degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for retinal degenerative diseases that cause blindness.
How similar studies have performed: Previous research on mutant mice has shown promising results in understanding the relationship between protein expression and retinal structure, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Makino, Clint L — Boston University Medical Campus
- Study coordinator: Makino, Clint L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.