Understanding how the stomach's shape develops and varies
Modeling stomach curvature: in vivo and in silico
['FUNDING_R01'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-11104165
This study looks at how the shape of the stomach develops and how it relates to the way organs form on the left and right sides of the body, which could help us understand birth defects that affect stomach shape and function.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-11104165 on ClinicalTrials.gov |
What this research studies
This research investigates the development of stomach curvature and its relationship to left-right asymmetry in organ formation. By examining both living organisms and computer models, the study aims to uncover the cellular and molecular processes that contribute to the stomach's unique shape. The researchers will explore how different tissue layers interact to create the proper curvature, which is crucial for normal stomach function. Patients may benefit from insights gained about birth defects related to stomach shape and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital birth defects related to stomach shape or function, particularly those with heterotaxy.
Not a fit: Patients without any congenital abnormalities or those not affected by stomach-related birth defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of birth defects associated with stomach curvature and other organ asymmetries.
How similar studies have performed: While the specific focus on stomach curvature is novel, previous research on left-right asymmetry in other organs has shown promising results.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NASCONE-YODER, NANETTE M — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: NASCONE-YODER, NANETTE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.