Understanding how the stomach's shape develops and varies
Official title: Modeling stomach curvature: in vivo and in silico
Funded at North Carolina State University Raleigh · NIH-11104165 · Data updated 2026-11-12
This study looks at how the shape of the stomach develops and how it relates to the way organs form on the left and right sides of the body, which could help us understand birth defects that affect stomach shape and function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | June 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $598,583 |
| NIH project number | 1R01HD117958-01 |
| Project ID | NIH-11104165 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital birth defects related to stomach shape or function, particularly those with heterotaxy.
✕Less likely to help
Patients without any congenital abnormalities or those not affected by stomach-related birth defects may not benefit from this research.
What this research studies
This research investigates the development of stomach curvature and its relationship to left-right asymmetry in organ formation. By examining both living organisms and computer models, the study aims to uncover the cellular and molecular processes that contribute to the stomach's unique shape. The researchers will explore how different tissue layers interact to create the proper curvature, which is crucial for normal stomach function. Patients may benefit from insights gained about birth defects related to stomach shape and function.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of birth defects associated with stomach curvature and other organ asymmetries.
How similar studies have gone: While the specific focus on stomach curvature is novel, previous research on left-right asymmetry in other organs has shown promising results.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Nascone-Yoder, Nanette M — North Carolina State University Raleigh
- Study coordinator: Nascone-Yoder, Nanette M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.