Understanding how the spleen stores immune memory against the flu virus
Investigating the human spleen as an archive of memory B cells reactive to the influenza virus hemagglutinin
['FUNDING_R21'] · UNIVERSITY OF ROCHESTER · NIH-11092946
This study is looking at how the spleen helps store special immune cells that remember past infections, like the flu, and it's for people who have had their spleen removed to understand how their immune response might change.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11092946 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the human spleen in storing memory B cells that respond to the influenza virus. By examining splenocytes from patients who have undergone spleen removal, the study aims to understand how these immune cells are modified and how they retain a memory of past infections. The researchers will focus on the influenza A virus hemagglutinin as a model to evaluate the composition and function of these memory B cells. This could provide insights into how the immune system remembers and responds to viral infections over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have had their spleens surgically removed due to trauma and have a history of influenza infections.
Not a fit: Patients who have not had their spleens removed or who do not have a history of influenza infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune memory, potentially leading to improved vaccines and therapies for influenza and other viral infections.
How similar studies have performed: Other research has shown success in understanding immune memory through similar approaches, particularly in the context of viral infections.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANGSTER, MARK Y — UNIVERSITY OF ROCHESTER
- Study coordinator: SANGSTER, MARK Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.