Understanding how the SOX2 gene influences squamous cancer development
Official title: SOX2 acts in the 3D genome of squamous cancer
Funded at University of Utah · NIH-11002322 · Data updated 2026-11-12
This study is looking at how a gene called SOX2 works in squamous cancer, which can affect places like the lungs and skin, to find new ways to help treat patients better.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $408,001 |
| NIH project number | 5R37CA263505-02 |
| Project ID | NIH-11002322 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with squamous cancer, particularly those with tumors expressing high levels of the SOX2 gene.
✕Less likely to help
Patients with squamous cancer who do not have SOX2 overexpression or those with other types of cancer may not benefit from this research.
What this research studies
This research investigates the role of the SOX2 gene in squamous cancer, which affects various organs such as the lungs and skin. It aims to uncover how SOX2 is activated and how it regulates other genes involved in cancer progression, using advanced techniques to study the 3D structure of the genome. By focusing on the interactions between different parts of the genome, the research seeks to identify new therapeutic targets that could lead to more effective treatments for patients with squamous cancer.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with squamous cancer.
How similar studies have gone: While the specific approach of studying SOX2 in the 3D genome context is novel, similar research has shown promise in identifying new cancer biomarkers and therapeutic targets.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Zhang, Xiaoyang — University of Utah
- Study coordinator: Zhang, Xiaoyang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.